10-Formyl-5,8-dideazafolic acid

Product Specifications

CAS Number

61038-31-1

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/Checkpoint|||DNA Damage/DNA Repair

Purity

0.9604

Bioactivity

10-Formyl-5,8-dideazafolic acid (CB3717) is a water-soluble analog of folic acid, also known as folate. Folate is a member of the B-vitamin family, which plays a supporting role in a number of key biochemical reactions in the body, including RNA and DNA synthesis. Made up of pteridine, para-aminobenzoic acid, and glutamate, 10-Formyl-5,8-dideazafolic acid is a compound that inhibits de novo folate metabolism. It induces cell cycle arrest at phase G (1) -S, disrupts repair of cells damaged by radiation, and induces apoptosis.

Smiles

Nc1nc(=O)c2cc(CN(C=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)ccc2[nH]1

Molecular Formula

C22H21N5O7

Molecular Weight

467.43

Shipping Conditions

Cool pack

Storage Temperature

-20°C