PD-1/PD-L1-IN 6
Product Specifications
CAS Number
2393983-76-9
Target
Others|||PD-1/PD-L1
Related Pathways
Others|||Immunology/Inflammation|||Apoptosis|||Cell Cycle/Checkpoint
Bioactivity
PD-1/PD-L1-IN 6 (compound A13) is a potent inhibitor of PD-1/PD-L1 interaction (IC50 = 132.8 nM) with outstanding immunoregulatory activity. In a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, PD-1/PD-L1-IN 6 significantly elevates interferon-? secretion without significant toxic effects. Additionally, in a T cell-tumor co-culture model, PD-1/PD-L1-IN 6 restores the immune response.
Smiles
C(=O)(N1C=2C(=C(C=CC2)C3=CC=CC=C3)CC1)C4=CC(OC)=C(CNCCO)C=C4
Molecular Formula
C25H26N2O3
Molecular Weight
402.49
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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