HPGDS inhibitor 3
Product Specifications
CAS Number
2255311-93-2
Target
Others|||PGE Synthase
Related Pathways
Immunology/Inflammation|||Others
Bioactivity
HPGDS inhibitor 3 is a powerful oral compound that selectively inhibits the hematopoietic prostaglandin D synthase (H-PGDS) . With an IC50 value of 9.4 nM and EC50 of 42 nM, it demonstrates high potency in peripherally restricting H-PGDS. Moreover, HPGDS inhibitor 3 exhibits excellent selectivity with no associated central nervous system toxicity. This compound also possesses favorable pharmacokinetic properties in mouse, rat, and dog models. Additionally, HPGDS inhibitor 3 displays noteworthy anti-inflammatory activity [1].
Smiles
C(N[C@@H]1CC[C@@H](C(C)(C)O)CC1)(=O)C2=CC3=C(N=C(C=C3)C4CC4)N=C2
Molecular Formula
C21H27N3O2
Molecular Weight
353.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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