NLRP3/AIM2-IN-3
Product Specifications
CAS Number
1787787-60-3
Target
NOD|||Pyroptosis|||NOD-like Receptor (NLR) |||AIM2
Related Pathways
Immunology/Inflammation|||NF-?B|||Apoptosis
Purity
0.9716
Bioactivity
NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 ? M. NLRP3/AIM2-IN-3 is a potent inhibitor of NLRP3 and AIM2 inflammasome-dependent cell lysis with an IC50 value for cell lysis of 0.077 ± 0.008 ? M. NLRP3/AIM2-IN-3 inhibits LPS/nigericin NLRP3/AIM2-IN-3 inhibits LPS/nigericin-stimulated cell lysis in THP-1 macrophages with an IC50 value of 0.077 ± 0.008 ?M. NLRP3/AIM2-IN-3 interferes with the interaction of NLRP3 or AIM2 with the bridging protein ASC, inhibiting oligomerization of ASC.
Smiles
Oc1cccc(NC(=O)Cc2ccc3cc[nH]c3c2)c1
Molecular Formula
C16H14N2O2
Molecular Weight
266.29
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
1bDPNVB-Stone 1 Plate
3.2 x 2.4 mm, 1.2 mm thick, <110> Orientation, Single Crystal Type 1b HPHT Plate with ~1.5 ppm NV Content, Ra < 0.50 um
Ask
View Details 
GTR15082262 1 Vial
Lentiviral human ATP2C1 shRNA (UAS) - Lentiviral human ATP2C1 shRNA (UAS, iRFP) (25)
Ask
View Details 