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WHI-P97 HCl

Product Specifications

Target

JAK

Related Pathways

Stem Cells|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||JAK/STAT signaling|||Angiogenesis

Purity

0.9949

Bioactivity

WHI-P97 HCl is a potent and selective JAK-3 inhibitor. WHI-P97 had an estimated Ki value of 0.09 microM from modeling studies and a measured IC50 value of 2.5 microM in EGFR kinase inhibition assays. WHI-P97 effectively inhibited the in vitro invasiveness of EGFR-positive human cancer cells in a concentration-dependent manner.

Smiles

COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C(=C3)Br)O)Br)OC.Cl

Molecular Formula

C16H14Br2ClN3O3

Molecular Weight

491.56

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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