PROTAC BRD4 Degrader-13

Product Specifications

CAS Number

2417370-71-7

Target

PROTAC-Linker Conjugates for PAC|||Epigenetic Reader Domain|||Others

Related Pathways

Chromatin/Epigenetic|||Others|||Antibody-drug Conjugate/ADC Related

Bioactivity

PROTAC BRD4 Degrader-13 (compound 9d) is a bioactive compound functioning as a proteolysis targeting chimera (PROTAC) by linking ligands for von Hippel-Lindau and BRD4 proteins. In PC3 prostate cancer cells, it effectively degrades the BRD4 protein through conjugation with STEAP1 and CLL1 antibodies, exhibiting a DC50 of 0.025 nM and 6.0 nM, respectively.

Smiles

Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@H](CN2C(=O)[C@@H](NC(=O)CCCCCCCCCCNC(=O)c2cc3N(Cc4c[nH]c5c4c(cn(C)c5=O)-c3cc2CS(C)(=O)=O)c2ncc(F)cc2F)C(C)(C)C)OP(O)(=O)OP(O)(=O)OCCNC(=O)CCCCCN2C(=O)C=CC2=O)cc1|c:103|