MD-222

Product Specifications

CAS Number

2136246-72-3

Target

MDM-2/p53|||PROTACs|||E1/E2/E3 Enzyme

Related Pathways

Apoptosis|||PROTAC|||Ubiquitination

Bioactivity

MD-222, a pioneering, highly potent PROTAC degrader targeting MDM2, efficiently mediates the rapid degradation of MDM2 protein and activates wild-type p53 within cells, showcasing significant anticancer effects[1][2].

Smiles

Fc1c(Cl)cccc1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)Nc2cc(Cl)ccc12)C(=O)Nc1ccc(cc1)C(=O)NCCCCCc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O

Molecular Formula

C48H47Cl2FN6O6

Molecular Weight

893.84

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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