AS-99 free base
Product Specifications
CAS Number
2323623-93-2
Target
Histone Methyltransferase|||Apoptosis|||Others
Related Pathways
Others|||Chromatin/Epigenetic|||Apoptosis
Bioactivity
AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC50= 0.79 ?M, Kd= 0.89 ?M) with anti-leukemic activity, blocking cell proliferation, inducing apoptosis and differentiation, downregulating MLL fusion target genes, and reducing the leukemia burden in vivo[1].
Smiles
CN1CC(C1)C(=O)NCc1ccc2c(cn(C3CCN(CC3)S(=O)(=O)C(F)(F)F)c2c1)-c1cccc(c1)C(N)=S
Molecular Formula
C27H30F3N5O3S2
Molecular Weight
593.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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