CAY10760
Product Specifications
CAS Number
391889-85-3
Target
DNA/RNA Synthesis|||Others
Related Pathways
Others|||DNA Damage/DNA Repair|||Cell Cycle/Checkpoint
Bioactivity
CAY10760 is an inhibitor of the protein-protein interaction between RAD51 recombinase and BRCA2 (EC50= 19 ?M in a cell-free competitive ELISA) .1It decreases homologous recombination by 54% in wild-typeBRCA2-expressing BxPC-3 pancreatic cancer cells when used at a concentration of 20 ?M. CAY10760 (20 ?M) decreases proliferation of BxPC-3, as well as mutantBRCA2-expressing Capan-1, cancer cells when used alone or in combination with the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib .
Smiles
CCC(=O)N1N=C(CC1C1=CC=C(OC)C=C1)C1=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC(Cl)=C2
Molecular Formula
C28H24ClN3O3
Molecular Weight
485.96
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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