Merestinib
Product Specifications
CAS Number
1206799-15-6
Target
ROS|||ROS Kinase|||FLT|||c-Met/HGFR|||Discoidin Domain Receptor (DDR)
Related Pathways
Angiogenesis|||Immunology/Inflammation|||Tyrosine Kinase/Adaptors
Purity
0.9971
Bioactivity
Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing the constitutively activated c-Met protein.
Smiles
O(C1=C(C=C2C(=C1)C=NN2C)C=3C=NNC3)C4=C(F)C=C(NC(=O)C=5C(=O)N(C(C)=CC5)C6=CC=C(F)C=C6)C=C4
Molecular Formula
C30H22F2N6O3
Molecular Weight
552.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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