Timosaponin AIII

Product Specifications

CAS Number

41059-79-4

Target

Cholinesterase (ChE) |||mTOR

Related Pathways

PI3K/Akt/mTOR signaling|||Neuroscience

Purity

0.9961

Bioactivity

Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 ?M) . The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 ?M, BT474 cells; 6 ?M, MDAMB231) . The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.

Smiles

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