KALA

KALA is an amphiphilic peptide that forms an α-helical structure at physiological pH. KALA modifies a plasmid DNA-encapsulating liposomal membrane and is used as a fusogenic peptide in order to achieve effective liver targeting and transfection of DNA via galactose receptors[1].

Product Specifications

CAS Number

[187987-64-0]

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/kala.html

Purity

96.10

Solubility

H2O : ≥ 50 mg/mL

Smiles

OC([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CS)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CC1=CN=CN1)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](C)NC([C@H](CCC(O)=O)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C144H248N40O35S

Molecular Weight

3131.82

References & Citations

[1]Naoya Miura, et al. Identification and Evaluation of the Minimum Unit of a KALA Peptide Required for Gene Delivery and Immune Activation. J Pharm Sci. 2017 Oct;106 (10) :3113-3119.