Senicapoc

Senicapoc (ICA-17043) is a potent and selective Gardos channel (Ca2+-activated K+ channel; KCa3.1) blocker with an IC50 of 11 nM. Senicapoc blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 nM and inhibits RBC dehydration with IC50 of 30 nM[1].

Product Specifications

CAS Number

[289656-45-7]

Product Name Alternative

ICA-17043

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/senicapoc.html

Purity

99.91

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(C1=CC=CC=C1)(C2=CC=C(C=C2)F)C3=CC=C(F)C=C3)N

Molecular Formula

C20H15F2NO

Molecular Weight

323.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Stocker JW, et al. ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cell dehydration in vitro and in vivo in SAD mice. Blood. 2003 Mar 15;101 (6) :2412-8.|[2]Van Der Velden J, et al. K (Ca) 3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. PLoS One. 2013 Jun 24;8 (6) :e66886.