SB-218078
Product Specifications
CAS Number
135897-06-2
Target
PKC|||Apoptosis|||Chk|||CDK
Related Pathways
Chromatin/Epigenetic|||Apoptosis|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling
Bioactivity
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM) . SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50: 15 nM) .
Smiles
O=C1NC(=O)c2c1c1c3ccccc3n3C4CCC(O4)n4c5ccccc5c2c4c13
Molecular Formula
C24H15N3O3
Molecular Weight
393.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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