Puromycin aminonucleoside
Product Specifications
CAS Number
58-60-6
Target
Apoptosis|||Proteasome|||Antibiotic|||Antibacterial|||Aminopeptidase
Related Pathways
Apoptosis|||Proteases/Proteasome|||Ubiquitination|||Metabolism|||Microbiology/Virology
Purity
0.9997
Bioactivity
Puromycin aminonucleoside (NSC 3056) is an aminonucleoside antibiotic and a purine analog of puromycin. It can reversibly inhibit dipeptidyl peptidase and cytosolic alanine aminopeptidase, increase podocyte permeability by regulating ZO-1 in an oxidative stress-dependent manner, induce apoptosis, and promote the secretion of migrasomes. It is commonly used to induce nephrotic syndrome models in research.
Smiles
CN(C)c1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](N)[C@H]1O
Molecular Formula
C12H18N6O3
Molecular Weight
294.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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