PF-06459988
Product Specifications
CAS Number
1428774-45-1
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis
Purity
0.98
Bioactivity
PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor. PF-06459988 has high efficiency and high affinity for EGFRs double mutants containing T790M, and has minimal activity against WT EGFR. PF-06459988 makes a candidate drug for the treatment of cancer.
Smiles
CO[C@H]1CN(C[C@@H]1COc1nc(Nc2cnn(C)c2)nc2[nH]cc(Cl)c12)C(=O)C=C
Molecular Formula
C19H22ClN7O3
Molecular Weight
431.88
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
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