2-Bromoacetamide

2-Bromoacetamide is a disinfection byproduct. 2-Bromoacetamide can inactivate liver alcohol dehydrogenase and interfere with microtubule and actin cytoskeletal function. 2-Bromoacetamide is a potent developmental toxicant in animals[1][2][3].

Product Specifications

CAS Number

[683-57-8]

UNSPSC

12352211

Hazard Statement

H301, H314

Target

Aldehyde Dehydrogenase (ALDH) ; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/2-bromoacetamide.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N)CBr

Molecular Formula

C2H4BrNO

Molecular Weight

137.96

Precautions

H301, H314

References & Citations

[1]Fries RW, et al. Activation of liver alcohol dehydrogenases by imidoesters generated in solution. Biochemistry. 1975;14 (23) :5233‐5238.|[2]Zhang C, et al. Developmental toxicity of 2-bromoacetamide on peri- and early post-implantation mouse embryos in vitro. Ecotoxicol Environ Saf. 2023 Mar 1;252:114612. |[3]Zhang C, et al. 2-bromoacetamide exposure impairs oocyte maturation in mice and humans primarily via disrupting the cytoskeleton. Ecotoxicol Environ Saf. 2024 Mar 1;272:116105.