6RK73

6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 µM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 µM) . 6RK73 specifically inhibit UCHL1 activity in breast cancer[1].

Product Specifications

CAS Number

[1895050-66-4]

UNSPSC

12352005

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6rk73.html

Concentration

10mM

Purity

98.41

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1CN(C#N)CC1)NC2=NC=C(N3CCOCC3)S2

Molecular Formula

C13H17N5O2S

Molecular Weight

307.37

References & Citations

[1]Liu S, et al. Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis. Clin Cancer Res. 2019 Dec 19. pii: clincanres.1373.2019.