VEGFR-2-IN-44
Product Specifications
UNSPSC Description
VEGFR-2-IN-44 (compound 4b) is a selective VEGF-R2 (Flk-1) inhibitor with an IC50 value of 70 nM. VEGFR-2-IN-44 also inhibits PDGF-Rβ with an IC50 of 920 nM[1].
Target Antigen
PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-44.html
Solubility
10 mM in DMSO
Smiles
O=C(/C(C1=C2)=C\C3=CC4=C(CCCC4)N3)NC1=CC=C2Br
Molecular Weight
343.22
References & Citations
[1]L Sun, et al. Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases. J Med Chem. 2000 Jul 13;43(14):2655-63.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112337/VEGFR-2-IN-44-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112337/
Clinical Information
No Development Reported
CAS Number
288144-20-7
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
