Sonlicromanol

Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease[1][2].

Product Specifications

CAS Number

[1541170-75-5]

Product Name Alternative

KH176

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sonlicromanol.html

Purity

99.75

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CC1=C(C(C)=C2CC[C@@](C(N[C@@H]3CCCNC3)=O)(OC2=C1C)C)O

Molecular Formula

C19H28N2O3

Molecular Weight

332.44

References & Citations

[1]X Jiang, et al. Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE 2 biosynthesis by sonlicromanol's metabolite KH176m. Sci Rep. 2021 Jan 13;11 (1) :880.|[2]Zikai Feng, et al. Comparative In Vitro Toxicology of Novel Cytoprotective Short-Chain Naphthoquinones. Pharmaceuticals (Basel) . 2020 Aug 7;13 (8) :184.|[3]Sanne J C M Frambach, et al. Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866 (6) :165727.