GRPP (human)

GRPP (human) is a 30 amino acid Gcg-derived peptide. GRPP (human) causes slight increases in plasma insulin and decreases in plasma glucagon. GRPP (human) does not affect insulin secretion in rat islets[1].

Product Specifications

CAS Number

[1132745-52-8]

UNSPSC

12352209

Target

GCGR

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/grpp-human.html

Purity

98.94

Solubility

10 mM in DMSO

Smiles

C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)CCSC)=O)CCC(N)=O)=O)CC(O)=O)(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)N)=O)CO)=O)CC(C)C)=O)CCC(N)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)CCC(O)=O)=O)CCC(O)=O)=O)CCCCN)=O)CO)=O)CCCNC(=N)N)=O)CO)=O)=O)CO)=O)C)=O)CO)=O)CCC(N)=O)=O)C)=O)CC(O)=O)=O)CCC2)CC(C)C)=O)CO)=O)CC(O)=O)=O)CCC1

Molecular Formula

C136H215N41O58S

Molecular Weight

3384.47

References & Citations

[1]Lynda Whiting, et al. Glicentin-related pancreatic polypeptide inhibits glucose-stimulated insulin secretion from the isolated pancreas of adult male rats. Physiol Rep. 2015 Dec;3 (12) :e12638.