PLX5622 hemifumarate
Product Specifications
Target
C-Fms
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
PLX5622 hemifumarate is a highly selective, blood-brain barrier-permeable, and orally active CSF1R inhibitor with an IC50 of 0.016 ?M and a Ki of 5.9 nM. It can be used to eliminate proliferating and specific microglia before and during disease progression and is applicable for inducing Alzheimer's disease models.
Smiles
COC1=NC=C(F)C=C1CNC2=NC(F)=C(CC3=CNC4=NC=C(C)C=C43)C=C2.O=C(O)/C=C/C(O)=O.[1/2]
Molecular Formula
C25H23F2N5O5
Molecular Weight
453.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
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