RIPK2-IN-5
RIPK2-IN-5 (compound 14) is a high affinity and excellent selectivity RIPK2 inhibitor with an IC50 value of 5.1nM. RIPK2-IN-5 has cellular anti-inflammatory effect and can reduce the secretion of MDP-induced TNF-α with a dose-dependent manner. RIPK2-IN-5 shows moderate stability in human liver microsome. RIPK2-IN-5 can be used for the research of immune diseases[1].
Product Specifications
CAS Number
[2885227-09-6]
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk2-in-5.html
Purity
99.73
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
C12=CC(NC3=CC=NC4=CC=C(C5=CC=NC=C5)C=C34)=CC=C1SC=N2
Molecular Formula
C21H14N4S
Molecular Weight
354.43
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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