RIPK2-IN-5
Product Specifications
UNSPSC Description
RIPK2-IN-5 (compound 14) is a high affinity and excellent selectivity RIPK2 inhibitor with an IC50 value of 5.1nM. RIPK2-IN-5 has cellular anti-inflammatory effect and can reduce the secretion of MDP-induced TNF-α with a dose-dependent manner. RIPK2-IN-5 shows moderate stability in human liver microsome. RIPK2-IN-5 can be used for the research of immune diseases[1].
Target Antigen
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk2-in-5.html
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
C12=CC(NC3=CC=NC4=CC=C(C5=CC=NC=C5)C=C34)=CC=C1SC=N2
Molecular Weight
354.43
References & Citations
[1]Fan T, et al. Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38(1):282-293.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157325/RIPK2-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157325/RIPK2-IN-5-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2885227-09-6
Available Sizes
Curated Selection
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