Mcl-1 inhibitor 3
Product Specifications
CAS Number
2376774-73-9
Target
Bcl-2 Family
Related Pathways
Apoptosis
Bioactivity
Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity.Mcl-1 inhibitor 3 is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay) .
Smiles
[H][C@@]12CC[C@@]1([H])[C@@H](OCCN1CC(F)(F)C1)\C=C/CCN(C)C(=O)C[C@](O)(C(=O)NS(=O)(=O)N(C)C)c1ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C2)c3c1|c:18|
Molecular Formula
C40H52ClF2N5O7S
Molecular Weight
820.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C
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