LV-320
Product Specifications
CAS Number
2449093-46-1
Target
Autophagy|||Cysteine Protease
Related Pathways
Proteases/Proteasome|||Autophagy
Bioactivity
LV-320 is a potent, uncompetitive ATG4B inhibitor with an IC50 of 24.5 ?M and a Kd of 16 ?M. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic, and active in vivo. These findings suggest that LV-320 will serve as a relevant chemical tool to study the various roles of ATG4B in cancer and other contexts [1].
Smiles
OC(=O)CCSC(SCCc1ccccc1)c1ccc(\C=C\c2ccnc3cc(Cl)ccc23)cc1
Molecular Formula
C29H26ClNO2S2
Molecular Weight
520.11
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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