Tuvusertib
Product Specifications
CAS Number
1613200-51-3
Target
ATM/ATR|||Chk|||Apoptosis
Related Pathways
DNA Damage/DNA Repair|||PI3K/Akt/mTOR signaling|||Apoptosis|||Cell Cycle/Checkpoint
Purity
0.9966
Bioactivity
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µ?) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks downstream phosphorylation of serine/threonine protein kinase checkpoint kinase 1 (CHK1), thereby inhibits DNA damage checkpoint activation, disrupting DNA damage repair and inducing apoptosis in tumor cells.
Smiles
Cn1cncc1-c1c(F)cncc1NC(=O)c1c(N)nn2cc(F)cnc12
Molecular Formula
C16H12F2N8O
Molecular Weight
370.32
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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