Coumalic acid

Coumalic acid is an inhibitor of human carbonic anhydrase (hCA) (KI = 0.073 μM for hCA IX; KI = 0.083 μM for hCA XII) . Coumalic acid is a valuable platform compound which can be prepared from malic acid. Coumalic acid can be used in the flavorings, fragrances and cosmetics industries, as polymer components, and pharmaceutical scaffolds. Coumalic acid displays antibronchial and antimalarial activity[1][2].

Product Specifications

CAS Number

[500-05-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Hydroxycarboxylic Acid Receptor (HCAR) ; Parasite

Type

Natural Products

Related Pathways

Anti-infection; GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/coumalic-acid.html

Purity

97.65

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C(C=C1)=COC1=O

Molecular Formula

C6H4O4

Molecular Weight

140.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Smith LK, et, al. Flow synthesis of coumalic acid and its derivatization. Department of Chemistry. 2018, 3: 722-732.|[2]Pontecorvi, V., et al., (2022) . Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies. International journal of molecular sciences, 23 (14), 7950.