GLI antagonist-1
Product Specifications
UNSPSC Description
GLI antagonist-1 is a potent GLI antagonist with an IC50 value of 1.1 μM. GLI antagonist-1 shows anti-proliferative activity. GLI antagonist-1 decreases the GLI1 mRNA expression. GLI antagonist-1 inhibits colony formation in a dose-dependent manner[1].
Target Antigen
Gli
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gli-antagonist-1.html
Purity
95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COCCOC(C1=C(C)NC(CC(C2=C(C=CC=C2)OC)CC3=O)=C3C1C4=CC(O)=CC=C4)=O
Molecular Weight
463.53
References & Citations
[1]Oladapo HO, et al. Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells. Cancer Lett. 2017 Dec 28;411:136-149.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-107551/GLI-antagonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-107551/GLI-antagonist-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
599150-20-6
Available Sizes
Curated Selection
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