Aspochalasin D

Aspochalasin D is a co-metabolite originally isolated from A. microcysticus with aspochalasins A, B, and C, that is initially thought to be inactive. It has antibacterial activity against Gram-positive and Gram-negative bacteria at a concentration of 1 mg/ml.2 Aspochalasin D is more cytotoxic, via apoptosis, to Ba/F3-V12 cells in an IL-3-free medium than in an IL-3-containing medium (IC50s=0.49 and 1.9 μg/mL, respectively) .

Product Specifications

CAS Number

[71968-02-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Bacterial

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/aspochalasin-d.html

Purity

95.0

Smiles

O=C1N[C@@H](CC(C)C)[C@]2([H])[C@H](C)C(C)=C[C@@](/C=C(C)/CC[C@@H](O)[C@@H](O)/C=C/3)([H])[C@]12C3=O

Molecular Formula

C24H35NO4

Molecular Weight

401.54

Precautions

H315, H319, H335

References & Citations

[1]Gebhardt, et al. Aspochalamins A-D and aspochalasin Z produced by the endosymbiotic fungus Aspergillus niveus LU 9575 I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. (Tokyo) 57 (11), 707-714 (2004) .