CycLuc1

CycLuc1 is a blood-brain barrier permeable luciferase substrate that displays near-infrared (NIR) emission with a peak luminescence wavelength of 599 nm. CycLuc1 can be used for in vivo bioluminescence imaging[1][2].

Product Specifications

CAS Number

[1247879-16-8]

UNSPSC

12171500

Hazard Statement

H302, H315, H319

Target

Reactive Oxygen Species (ROS)

Type

Dye Reagents

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/CycLuc1.html

Purity

99.72

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C([C@@H]1N=C(C2=NC3=CC4=C(NCC4)C=C3S2)SC1)O

Molecular Formula

C13H11N3O2S2

Molecular Weight

305.38

Precautions

H302, H315, H319

References & Citations

[1]Shiv K, et al. Abstract 4112: Synthetic luciferin, CycLuc1, improves bioluminescence imaging for intracranial glioblastoma xenografts. 10.1158/1538-7445.AM2018-4112|[2]Evans MS, et al. A synthetic luciferin improves bioluminescence imaging in live mice. Nat Methods. 2014 Apr;11 (4) :393-5. doi: 10.1038/nmeth.2839. Epub 2014 Feb 9. Erratum in: Nat Methods. 2014 Apr;11 (4) :395.