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SR 11023

Product Specifications

UNSPSC Description

SR 11023 is an orally active antagonist of PPARγ, with the IC50 value of 109 nM that plays an important role in diabetic research[1].

Target Antigen

PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sr-11023.html

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](C1=CC(C2CC2)=CC=C1)NC(C3=CC=C(C(C(C)=C4C)=C3)N4CC5=CC=C(C=C5)C(C)(C)C(O)=O)=O

Molecular Weight

508.65

References & Citations

[1]J Mukherjee, et al. Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism. Nucl Med Biol. 1995 Apr;22(3):283-96.

Shipping Conditions

Room Temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-160162/SR-11023-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-160162/SR-11023-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1820602-13-8

Available Sizes

Curated Selection

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