8-Chloro caffeine
Product Specifications
UNSPSC Description
8-Chloro caffeine binds to adenosine receptors (Ki = 30 µM). 8-Chloro caffeine potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine[1][2].
Target Antigen
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8-chloro-caffeine.html
Smiles
O=C1C2=C(N(C)C(N1C)=O)N=C(N2C)Cl
Molecular Weight
228.64
References & Citations
[1]Nilsson K, et al. The effect of methylated oxypurines on the size of newly-synthesized DNA and on the production of chromosome aberrations after UV irradiation in Chinese hamster cells. Mutat Res. 1975 Nov;30(2):255-66. |[2]Bruns RF. Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts. Biochem Pharmacol. 1981 Feb 15;30(4):325-33.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W178327/8-Chloro-caffeine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W178327/
Clinical Information
No Development Reported
CAS Number
4921-49-7
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