8-Chloro caffeine

8-Chloro caffeine binds to adenosine receptors (Ki = 30 µM) . 8-Chloro caffeine potentiates UV-induced chromosomal aberrations in Cl-I Chinese hamster embryonic lung cells. 8-Chloro caffeine is a derivative of the methylxanthine alkaloid caffeine[1][2].

Product Specifications

CAS Number

[4921-49-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/8-chloro-caffeine.html

Purity

99.43

Solubility

DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C2=C(N(C)C(N1C)=O)N=C(N2C)Cl

Molecular Formula

C8H9ClN4O2

Molecular Weight

228.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Nilsson K, et al. The effect of methylated oxypurines on the size of newly-synthesized DNA and on the production of chromosome aberrations after UV irradiation in Chinese hamster cells. Mutat Res. 1975 Nov;30 (2) :255-66. |[2]Bruns RF. Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts. Biochem Pharmacol. 1981 Feb 15;30 (4) :325-33.