(rel) -ML-SI3

(rel) -ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis) -ML-SI3) that targets three isoforms of TRPML. (rel) -ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM) [1][2][3].

Product Specifications

CAS Number

[2108567-79-7]

Product Name Alternative

Trans-ML-SI3

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; TRP Channel

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rel-ml-si3.html

Purity

98.94

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(N[C@H]1[C@H](N2CCN(C3=C(C=CC=C3)OC)CC2)CCCC1)(C4=CC=CC=C4)=O

Molecular Formula

C23H31N3O3S

Molecular Weight

429.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Rühl P, et al. Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. Sci Rep. 2021 Apr 15;11 (1) :8313. [Content Brief]|[2]Xing Y, et al. Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy. Basic Res Cardiol. 2022 Apr 7;117 (1) :20. [Content Brief]|[3]Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.