(rel)-ML-SI3
Product Specifications
UNSPSC Description
(rel)-ML-SI3 is one of the active ingredients of ML-SI3 (HY-139426) (another component is (cis)-ML-SI3) that targets three isoforms of TRPML. (rel)-ML-SI3 is an inhibitor of TRPML1 and TRPML3 (IC50=3.1 μM/28.5 μM), and a potent activator of TRPML2 (EC50=3.3 μM)[1][2][3].
Target Antigen
Autophagy; TRP Channel
Type
Reference compound
Related Pathways
Autophagy;Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rel-ml-si3.html
Smiles
O=S(N[C@H]1[C@H](N2CCN(C3=C(C=CC=C3)OC)CC2)CCCC1)(C4=CC=CC=C4)=O
Molecular Weight
429.58
References & Citations
[1]Rühl P, et al. Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors. Sci Rep. 2021 Apr 15;11(1):8313. [Content Brief]|[2]Xing Y, et al. Blunting TRPML1 channels protects myocardial ischemia/reperfusion injury by restoring impaired cardiomyocyte autophagy. Basic Res Cardiol. 2022 Apr 7;117(1):20. [Content Brief]|[3]Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139426A/rel-ML-SI3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139426A/rel-ML-SI3-SDS-MedChemExpress.pdf
CAS Number
2108567-79-7
Available Sizes
Curated Selection
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