Hydroflumethiazide

Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas[1][2][3].

Product Specifications

CAS Number

[135-09-1]

Product Name Alternative

Methforylthiazidine; Rontyl

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Chloride Channel; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hydroflumethiazide.html

Purity

99.38

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=S(C1=C(C(F)(F)F)C=C(C2=C1)NCNS2(=O)=O)(N)=O

Molecular Formula

C8H8F3N3O4S2

Molecular Weight

331.30

Precautions

H317, H334

References & Citations

[1]Selvaag E, et al. Phototoxicity to sulphonamide derived oral antidiabetics and diuretics. Comparative in vitro and in vivo investigations. In Vivo. 1997 Jan-Feb;11 (1) :103-7.|[2]Brørs O, et al. Pharmacokinetics of a single oral dose of hydroflumethiazide in health and in cardiac failure.-. Eur J Clin Pharmacol. 1978 Nov 9;14 (1) :29-37.|[3]Hermansen K, et al. Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro. Metabolism. 1985 Aug;34 (8) :784-9.