AR-A014418

AR-A014418 is a potent, selective and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM) [1].

Product Specifications

CAS Number

[487021-52-3]

Product Name Alternative

AR 0133418; GSK 3β inhibitor VIII; AR 014418

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/AR-A014418.html

Concentration

10mM

Purity

99.21

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NCC1=CC=C(OC)C=C1)NC2=NC=C([N+]([O-])=O)S2

Molecular Formula

C12H12N4O4S

Molecular Weight

308.31

Precautions

H302, H315, H318, H335

References & Citations

[1]Bhat R, Xue Y, Berg S, Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem. 2003 Nov 14;278 (46) :45937-45.|[2]Carter YM, et al. Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth. Cancer Biol Ther. 2014 May;15 (5) :510-5.|[3]Koh SH, et al. Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS. Exp Neurol. 2007 Jun;205 (2) :336-46|[4]Martins DF, et al. The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice. J Pain. 2011 Mar;12 (3) :315-22.