Garcinone D

Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM) . Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer[1][2].

Product Specifications

CAS Number

[107390-08-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Keap1-Nrf2; Reactive Oxygen Species (ROS) ; STAT

Type

Natural Products

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/garcinone-d.html

Purity

99.88

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)(O)CCC1=C(OC)C(O)=CC(OC2=CC(O)=C(C/C=C(C)/C)C(O)=C23)=C1C3=O

Molecular Formula

C24H28O7

Molecular Weight

428.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Yang X, et al. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 Jul 28;626:6-12.|[2]Nauman MC, et al. Inhibition of CDK2/CyclinE1 by xanthones from the mangosteen (Garcinia mangostana) : a structure-activity relationship study. Nat Prod Res. 2021 Dec;35 (23) :5429-5433.