SP600125
SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis[1][2][3].
Product Specifications
CAS Number
[129-56-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; Ferroptosis; JNK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SP600125.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : 11.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C3C(NN=C3C4=C1C=CC=C4)=CC=C2
Molecular Formula
C14H8N2O
Molecular Weight
220.23
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3
Available Sizes
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