Hydroxy-PEG4-acid
Hydroxy-PEG4-acid is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Hydroxy-PEG4-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Product Specifications
CAS Number
[937188-59-5]
Product Name Alternative
2-APV; DL-2-Amino-5-phosphonovaleric acid
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hydroxy-peg4-acid.html
Purity
99.81
Solubility
DMSO : 200 mg/mL (ultrasonic) |Ethanol : ≥ 200 mg/mL
Smiles
OC(CCOCCOCCOCCOCCO)=O
Molecular Formula
C11H22O7
Molecular Weight
266.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Tinya Abrams, et al. Antibody drug conjugates. WO2016203432A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Non-cleavable Linker; PEG Linkers
Available Sizes
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