Saintopin

Saintopin is an antitumor antibiotic. Saintopin is also an inhibitor of DNA topoisomerases I and II. Saintopin induces DNA cleavage[1][2].

Product Specifications

CAS Number

[131190-63-1]

Product Name Alternative

UCT-1003

UNSPSC

12352005

Target

Antibiotic; Topoisomerase

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/saintopin.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(O)=CC(O)=C1C2=O)C3=C2C(O)=C4C(O)=CC(O)=CC4=C3

Molecular Formula

C18H10O7

Molecular Weight

338.27

References & Citations

[1]Yamashita Y, et al. Saintopin, a new antitumor antibiotic with topoisomerase II dependent DNA cleavage activity, from Paecilomyces. J Antibiot (Tokyo) . 1990 Oct;43 (10) :1344-6.|[2]eteurtre F, et al. Saintopin, a dual inhibitor of DNA topoisomerases I and II, as a probe for drug-enzyme interactions. J Biol Chem. 1994 Nov 18;269 (46) :28702-7.