BI 653048
Product Specifications
UNSPSC Description
BI 653048 is a selective and orally active nonsteroidal?glucocorticoid (GC)?agonist with an IC50 value of 55 nM[1]. BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM)[2]. BI 653048 is extracted from patent WO2005028501A1 (Compound 103), is also a?HCV NS3 protease?inhibitor that can reduce viral loads infected with the?hepatitis C?virus[3].
Target Antigen
Cytochrome P450; Glucocorticoid Receptor; HCV Protease
Type
Reference compound
Related Pathways
Anti-infection;Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bi-653048.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N)C1=CC(F)=CC=C1C(C)(C)C[C@@](O)(CC(N2)=CC3=C2C=NC(S(=O)(CC)=O)=C3)C(F)(F)F
Molecular Weight
515.52
References & Citations
[1]Reeves JT, et al. Development of a large scale asymmetric synthesis of the glucocorticoid agonist BI 653048 BS H3PO4.J Org Chem. 2013 Apr 19;78(8):3616-35.|[2]Montse Llinas-Brunet, et al. Latest bibliographic data on file with the International Bureau|[3]Harcken C, et al. Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.ACS Med Chem Lett. 2014 Nov 20;5(12):1318-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12946/BI-653048-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12946/BI-653048-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
1198784-72-3
Available Sizes
Curated Selection
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