TML-6

TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ) . TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-oxidative Nrf2 gene. TML-6 has the potential for Alzheimer’s disease (AD) research[1].

Product Specifications

CAS Number

[1462868-88-7]

UNSPSC

12352005

Target

Amyloid-β; Keap1-Nrf2; mTOR; NF-κB

Type

Reference compound

Related Pathways

Neuronal Signaling; NF-κB; PI3K/Akt/mTOR

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tml-6.html

Purity

99.01

Solubility

DMSO : 120 mg/mL (ultrasonic)

Smiles

O=C(N(CC)CC)CC(C)(C(/C=C/C1=CC=C(OC)C(OC)=C1)=O)C(/C=C/C2=CC=C(OC)C(OC)=C2)=O

Molecular Formula

C30H37NO7

Molecular Weight

523.62

References & Citations

[1]Ih-Jen Su, et al. A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. Int J Mol Sci. 2020 Jul 30;21 (15) :5459.