Triacetin

Triacetin (Glyceryl triacetate) is a synthetic compound that is a triester of glycerol and acetic acid, orally active. Triacetin increases acetate bioavailability in glioma cells. Triacetin induces glioma cell growth arrest and Apoptosis. Triacetin freely crosses the blood brain barrier/plasma membrane. Triacetin increases histone acetylation and enhances Temozolomide (HY-17364) (TMZ) chemotherapeutic efficacy [1][2].

Product Specifications

CAS Number

[102-76-1]

Product Name Alternative

Glyceryl triacetate; 1,2,3-Triacetoxypropane

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Triacetin.html

Purity

99.87

Solubility

DMSO : 300 mg/mL (ultrasonic)

Smiles

CC(OCC(OC(C)=O)COC(C)=O)=O

Molecular Formula

C9H14O6

Molecular Weight

218.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Tsen AR, et al. Triacetin-based acetate supplementation as a chemotherapeutic adjuvant therapy in glioma. Int J Cancer. 2014 Mar 15;134 (6) :1300-10.|[2]Mekala JR, et al. N-acetyl l-aspartate and Triacetin modulate tumor suppressor MicroRNA and class I and II HDAC gene expression induce apoptosis in Glioblastoma cancer cells in vitro. Life Sci. 2021 Dec 1;286:120024.