A-3 (hydrochloride)
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It against PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM) and myosin light chain kinase (MLCK) (Ki=7.4 μM) . A-3 hydrochloride also inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1].
Product Specifications
CAS Number
[78957-85-4]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
CaMK; Casein Kinase; PKA; PKC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/a-3-hydrochloride.html
Purity
99.75
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCN)=O.[H]Cl
Molecular Formula
C12H14Cl2N2O2S
Molecular Weight
321.22
Precautions
H315, H319, H335
References & Citations
[1]Inagaki M, et al. Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol Pharmacol. 1986 Jun;29 (6) :577-81.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CK1; CK2; PKA; PKC
Available Sizes
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