Feniralstat
Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC50 of 6.7 nM for Human plasma kallikrein (pKal) . Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC50>40 μM) [1].
Product Specifications
CAS Number
[2166320-76-7]
Product Name Alternative
KVD-824
UNSPSC
12352005
Target
Kallikrein
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/feniralstat.html
Purity
99.12
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C=CC(F)=CN1CC2=CC=C(CN3N=C(COC)C(C(NCC4=NC=CC(OC)=C4F)=O)=C3)C=C2
Molecular Formula
C26H25F2N5O4
Molecular Weight
509.50
References & Citations
[1]Rebecca Louise DAVIE, et al. Pyrazole derivatives as plasma kallikrein inhibitors. WO2017207983A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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