FeTPPS

FeTPPS, a 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrin iron III chloride peroxynitrite decomposition catalyst, possesses evident neuroprotective effects in a experimental model of spinal cord damage[1]. FeTPPS acts as a peroxynitrite scavenger and anti-nitrating agent in vivo. FeTPPS reduces nitric oxide (NO) production and apoptosis process[2].

Product Specifications

CAS Number

[90384-82-0]

UNSPSC

12352005

Target

Apoptosis; NO Synthase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fetpps.html

Purity

99.9

Solubility

H2O : 5 mg/mL (ultrasonic; warming)

Smiles

O=S([O-])(C1=CC=C(C(C(C=C2)=[N]3C2=C(C4=CC=C5C(C6=CC=C(S(=O)([O-])=O)C=C6)=C7C=C8)C9=CC=C(S(=O)([O-])=O)C=C9)=C%10C=CC%11=C(C%12=CC=C(S(=O)([O-])=O)C=C%12)C8=[N]7[Fe+3]3([Cl-])([N-]45)[N-]%10%11)C=C1)=O.[4H+]

Molecular Formula

C44H28ClFeN4O12S4

Molecular Weight

1024.27

References & Citations

[1]Giuseppe Bruschetta, et al. FeTPPS Reduces Secondary Damage and Improves Neurobehavioral Functions after Traumatic Brain Injury.Front Neurosci. 2017 Feb 7;11:6. |[2]Pengfei Zhang, et al. Study on the detoxification mechanisms to 5,10,15,20-tetrakis (4-sulfonatophenyl) porphyrinato iron (III) chloride (FeTPPS), an efficient pro-oxidant of heme water-soluble analogue. J Inorg Biochem. 2018 Dec;189:40-52.