Ligustilide

Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects[1][2][3].

Product Specifications

CAS Number

[4431-01-0]

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Autophagy

Type

Natural Products

Related Pathways

Apoptosis; Autophagy

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Ligustilide.html

Purity

99.17

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1O/C(C2=C1C=CCC2)=C\CCC

Molecular Formula

C12H14O2

Molecular Weight

190.24

Precautions

H301

References & Citations

[1]Wu Q, et al. Protective effect of ligustilide against glutamate-induced apoptosis in PC12 cells. Yao Xue Xue Bao. 2015 Feb;50 (2) :162-8.|[2]Jing Ma, et al. Ligustilide promotes apoptosis of cancer-associated fibroblasts via the TLR4 pathways. Food Chem Toxicol. 2020 Jan;135:110991.|[3]Eun Sik Choi, et al. Ligustilide attenuates vascular inflammation and activates Nrf2/HO-1 induction and, NO synthesis in HUVECs. Phytomedicine. 2018 Jan 1;38:12-23.