Recombinant Human U7 snRNA-associated Sm-like protein LSm10 (LSM10)
Product Specifications
Product Name Alternative
LSM10U7 snRNA-associated Sm-like protein LSm10
Abbreviation
Recombinant Human LSM10 protein
Gene Name
LSM10
UniProt
Q969L4
Expression Region
1-123aa
Organism
Homo sapiens (Human)
Target Sequence
MAVSHSVKERTISENSLIILLQGLQGRVTTVDLRDESVAHGRIDNVDAFMNIRLAKVTYTDRWGHQVKLDDLFVTGRNVRYVHIPDDVNITSTIEQQLQIIHRVRNFGGKGQGRWEFPPKNCK
Tag
N-terminal 6xHis-SUMO-tagged
Type
Developed Protein
Source
E.coli
Field of Research
Transcription
Relevance
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.
Endotoxin
Not test
Purity
Greater than 90% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Function
Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to U7 snRNA. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.
Molecular Weight
30.1 kDa
References & Citations
Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14KDA Sm D1-like protein.Pillai R.S., Will C.L., Luehrmann R., Schuemperli D., Mueller B.EMBO J. 20:5470-5479 (2001)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Full Length
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1373108-01 0.02 mg (E-Coli)
Recombinant Rickettsia sibirica Undecaprenyl pyrophosphate synthase (uppS)
Ask
View Details 
MBS1373108-02 0.1 mg (E-Coli)
Recombinant Rickettsia sibirica Undecaprenyl pyrophosphate synthase (uppS)
Ask
View Details MBS1373108-03 0.02 mg (Yeast)
Recombinant Rickettsia sibirica Undecaprenyl pyrophosphate synthase (uppS)
Ask
View Details MBS1373108-04 0.1 mg (Yeast)
Recombinant Rickettsia sibirica Undecaprenyl pyrophosphate synthase (uppS)
Ask
View Details 
MBS1373108-05 0.02 mg (Baculovirus)
Recombinant Rickettsia sibirica Undecaprenyl pyrophosphate synthase (uppS)
Ask
View Details MBS1373108-06 0.02 mg (Mammalian-Cell)
Recombinant Rickettsia sibirica Undecaprenyl pyrophosphate synthase (uppS)
Ask
View Details