Dapsone-13C12

Dapsone-13C12 is the 13C12 labeled Dapsone (HY-B0688) . Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[1][2][3][4][5].

Product Specifications

CAS Number

[1632119-29-9]

Product Name Alternative

4,4′-Diaminodiphenyl sulfone-13C12; DDS-13C12

UNSPSC

12352005

Hazard Statement

H302

Target

Antibiotic; Bacterial; Isotope-Labeled Compounds; Parasite; Reactive Oxygen Species (ROS)

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dapsone-13c12.html

Solubility

10 mM in DMSO

Smiles

O=S([13C]1=[13CH][13CH]=[13C]([13CH]=[13CH]1)N)([13C]2=[13CH][13CH]=[13C]([13CH]=[13CH]2)N)=O

Molecular Formula

13C12H12N2O2S

Molecular Weight

260.21

Precautions

P264-P270-P330-P501

References & Citations

[1]D Voeller, et al. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone) .J Infect Dis. 1994 Feb;169 (2) :456-9.|[2]Dapsone, Drug.com|[3]Esther Moreno, et al. Evaluation of Skin Permeation and Retention of Topical Dapsone in Murine Cutaneous Leishmaniasis Lesions.Pharmaceutics. 2019 Nov 13;11 (11) :607.|[4]Y I Zhu, et al. Dapsone and sulfones in dermatology: overview and update. J Am Acad Dermatol|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.